Concepts of Genetics 12th Edition

Pdf Book Name: Concepts of Genetics 12th Edition
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: Pearson
ISBN-10, 13: 0134818970,9780134818979
Year: 2019
Pages: 867 pages
Language: English
File size: 64 MB
File format: PDF,EPUB

Concepts of Genetics 12th Edition Pdf Book Description:

It is essential that textbook authors step back and look with fresh eyes as each edition of their work is planned. In doing so, two main questions must be posed: (1) How has the body of information in their field—in this case, Genetic grown and shifted since the last edition? (2) Which pedagogic innovations that are currently incorporated into the text should be maintained, modified, or deleted? The preparation of the 12th edition of Concepts of Genetics, a
text well into its fourth decade of providing support for students studying in this field, has occasioned still another fresh look. And what we focused on in this new edition, in addition to the normal updating that is inevitably required, were three things. The importance of continuing to provide comprehensive coverage of important, emerging topics. In this regard, we continue to include a unique approach in genetics textbooks that offers readers a set of abbreviated, highly focused chapters that we label Special Topics in Modern Genetics. In this edition, these provide unique, cohesive coverage of six important topics: CRISPR-Cas and Genomic Editing, DNA Forensics, Genomics and Precision Medicine, Genetically Modified Foods, Gene Therapy, and Advances in Neurogenetics: The Study of Huntington Disease. The initial and final chapters in this series are both new to this edition.The recognition of the vastly increased knowledge resulting from the study of gene regulation in eukaryotes. To that end, the single chapter on this topic in previous editions has been expanded to three chapters “Transcriptional Regulation in Eukaryotes” (Chapter 17), “Posttranscriptional Regulation in Eukaryotes” (Chapter 18), and “Epigenetic Regulation of Gene Expression” (Chapter 19).

This extended coverage reflects many recent discoveries that reveal that RNA in many forms other than those that are essential to the process of transcription and translation (mRNA, tRNA, and rRNA) play critical roles in the regulation of eukaryotic gene activity. As well, it is now clear based on molecular studies related to epigenetics that this topic is best taught as an integral part of eukaryotic gene regulation. This new material provides the student exposure to modern coverage of a significant research topic.New to this edition are four chapters. Two are Special Topics in Modern Genetics entries entitled “CRISPR-Cas and Genome Editing” and “Advances in Neurogenetics: The Study of Huntington Disease.” Both cover cutting-edge information and represent very recent breakthroughs in genetics. CRISPR, a genome-editing tool, is a straightforward technique that allows specific, highly accurate modification of DNA sequences within genes and is thus a powerful tool in the world of genetic research and gene therapy. In addition to this chapter, we call your attention to the introduction to Chapter 1 for an introduction to CRISPR and to also note that we have chosen this gene editing system as the subject matter illustrated on the cover. Special Topics Chapter 6 illustrates the many of advances that have been made in the study of human neurogenetics. Huntington disease, a monogenic human disorder, has been subjected to analysis for over 40 years using every major approach and technique developed to study molecular genetics, and as such, exemplifies the growing body of information that has accrued regarding its causes, symptoms, and future treatment.

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